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Published on: 2011-06-21
Released on: 2011-06-21
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“About 25 years ago, Mosmann Coffman introduced the TH1 / TH2 paradigm of T helper cell differentiation which helped explain many aspects of adaptive immunity from eliminating intracellular versus extracellular pathogens to induction of different types of tissue inflammation. However, TH1 / TH2 paradigm could not adequately explain development of certain inflammatory responses which provided impetus for the discovery of a new subset of T cells called TH17 cells. After the discovery of differentiation and transcription factors for TH17 cells, it was clear that TH17 cells represent an independent subset of T cells with specific functions in eliminating certain extracellular pathogens, presumably not adequately handled by TH1 or TH2 cells. The major role of TH17 cells has been described in inducing auto-immune tissue inflammation.The discovery of TH17 cells has expanded the TH1 / TH2 paradigm, and the integration of TH17 cells with TH1 and TH2 effector T cells is beginning to explain the underlying mechanisms of tissue inflammation in a number of infections and auto-immune disease settings.”- From Chapter One by Vijay K. Kuchroo, Harvard University, USA“The recently identified Interleukin 17 (IL-17) cytokine family contributes to immunity to infectious diseases and chronic inflammatory diseases. Further studies on the regulation and function of this important cytokine family may provide better understanding on the roles of the IL-17 family in immune-mediated diseases; such knowledge may lead to the development of immunotherapeutic strategies for treatment of several inflammatory diseases.”- From Chapter Two by Chen Dong, University of Texas and MD Anderson Cancer Center, USA T Cells and Their Potential for Immunotherapy How to cite this article: Wu YL Ding YP Tanaka Y Shen LW Wei CH Minato N Zhang W. T Cells and Their Potential for Immunotherapy. Int J Biol Sci 2014; 10(2 ... Interleukin-2 and Regulatory T Cells in Graft-versus-Host ... Original Article. Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease. John Koreth M.B. B.S. D.Phil. Ken-ichi Matsuoka M.D. Ph.D. Haesook T. Kim ... Expanded allogeneic adipose-derived mesenchymal stem cells ... Background. Complex perianal fistulas in Crohn's disease are challenging to treat. Allogeneic expanded adipose-derived stem cells (Cx601) are a promising new ... How Chewing Triggers Your Immune System Men's Health People who eat quickly are more likely to become obese as we previously reported. But there may be one other surprising benefit to slowing down at the table: Chewing ... Research reveals surprising health benefits of chewing ... Scientists have shown that chewing your food properly can boost your mouths immune system to protect you against illness. The study led by teams at The University ... Factors responsible for chronic nature of autoimmune ... "We wanted to know the precise factors that maintain memory in Th17 cells so that we can better understand what is causing chronic autoimmune disorders" said senior ... Interleukin-33 in health and disease : Nature Reviews ... Previous article. Nature Reviews Immunology Review Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis ChemoCentryx Chronic Kidney Disease Diabetic nephropathy (DN) is a way of life for about 40 percent of all people who have Type 2 diabetes. Right now many patients with DN a form of chronic kidney ... BrainImmune: Trends in Neuroendocrine Immunology Expert ... Expert views & state of art in neuroendocrine immunology & stress-immunity research by BrainImmune.com. Both fundamental & clinical aspects and their impacts on ... Keystone Symposia Scientific Conferences on Biomedical ... KEYWORD(S) ENTERED: WOULD RETURN... Aiken: James Aiken Jim Aiken Robert Aiken Walter Aikenstein: James AND Aiken: James Aiken James W. Aiken James R. Aiken
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